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For Expert nutritional advice Contact Alan Gordon MSc. Clinical Nutrition
For Expert nutritional advice Contact Alan Gordon MSc. Clinical Nutrition
Antioxidant-rich foods including oranges, peppers, almonds, salmon, and Brazil nuts on a marble countertop

Vitamin C vs E vs Selenium: Which Antioxidant Wins?

Ever feel like you're fighting a battle you can't see? Every day, your body is under attack from unstable molecules called free radicals. These molecules are a natural by-product of metabolism but are also generated by exposure to pollution and UV rays. Left unchecked, they can cause oxidative stress, damaging cells and contributing to ageing and illness. The good news is, you have a powerful defence system: antioxidants. But with so many to choose from, which one is the champion?
This article cuts through the noise to compare three of the most powerful antioxidant nutrients: Vitamin C, Vitamin E, and Selenium. We will explore the specific benefits of each, how they work together, and how much you actually need. No fluff, just clear, evidence-based information to help you make the best choice for your health.

The Contenders: A Closer Look

First, let's meet our three antioxidant powerhouses. While they all protect the body, they operate in different ways. Vitamin C is a water-soluble all-rounder essential for your immune system. Vitamin E is a fat-soluble protector that excels at defending cell membranes. And Selenium is a specialist trace mineral, crucial for creating the body's own powerful antioxidant enzymes.

Vitamin C: The Immune Defender

Vitamin C is perhaps the most famous antioxidant, and for good reason. Its primary role is to support the immune system and maintain skin health. As the confirms, it is vital for protecting cells and helping with wound healing. It achieves this by stimulating the production and function of white blood cells, which are essential for fighting off infections.
It is also a key building block for collagen, the protein that gives skin its structure and elasticity. This makes it a go-to nutrient for anyone looking to maintain skin vitality and support recovery. Because it's water-soluble, your body can't store it, meaning a consistent daily intake is essential, especially for those with active lifestyles or during colder months.

Vitamin E: The Cell Guardian

Vitamin E is the body's primary fat-soluble antioxidant, acting as a dedicated guardian for your cells. Its main job is to integrate into cell membranes and protect them from oxidative damage, a process called lipid peroxidation. This protection is crucial for maintaining the integrity of every cell in your body, from your skin to your internal organs.
The highlights its role in maintaining healthy skin and eyes and strengthening the immune system. Its ability to protect cell membranes makes it particularly valuable for anti-ageing support, helping to shield skin from the environmental damage that leads to fine lines and wrinkles. Individuals looking to protect their bodies from the daily grind of oxidative stress will find Vitamin E to be an indispensable ally.

Selenium: The Master Enabler

Selenium is a trace mineral that punches well above its weight. Its most critical function is to act as a component of powerful antioxidant enzymes, most notably glutathione peroxidase. This enzyme is often called the body's master antioxidant, and Selenium is essential for it to function.
Furthermore, Selenium plays a vital role in thyroid health. The thyroid gland has the highest concentration of Selenium in the body, where it is essential for the metabolism of thyroid hormones. As the highlights, studies have shown that selenium supplementation can have a significant beneficial effect on thyroid health, particularly in cases of autoimmune thyroid conditions. This makes it a critical nutrient for anyone with thyroid concerns or those looking to optimise their body's own powerful antioxidant systems.

The Power of Teamwork: Antioxidant Synergy

Here’s where it gets interesting. While each antioxidant is a hero in its own right, they work even better as a team. Think of it as a well-drilled unit. When Vitamin E neutralises a free radical, it becomes inactive. Vitamin C then steps in to regenerate Vitamin E, bringing it back into the fight. This recycling process dramatically enhances the body's overall protective capacity.
Selenium adds another layer to this teamwork. As a core component of the enzyme glutathione peroxidase, it helps create a powerful, built-in antioxidant network that works alongside Vitamin C and E. This means that a balanced intake of all three is far more effective than a high dose of just one. A diet rich in a variety of antioxidant sources is the best strategy for comprehensive protection.

Getting What You Need: Doses and Food Sources

So, how much do you need, and where can you find them? The UK’s provides clear, no-nonsense guidelines. For Vitamin C, adults need around 40mg per day, which can be found in citrus fruits, peppers, strawberries, and broccoli. For Vitamin E, the recommendation is 4mg for men and 3mg for women, easily sourced from almonds, sunflower seeds, and olive oil. For Selenium, the target is 75µg for men and 60µg for women, with top sources including Brazil nuts, fish, meat, and eggs.
While a balanced diet should provide what you need, modern lifestyles and dietary habits can sometimes leave gaps. If you feel you need extra support, a high-quality supplement can be a convenient and reliable way to top up your levels.

The Verdict: And the Winner Is…

There is no single winner in this contest. The best antioxidant for you depends entirely on your individual health goals. For general immune support and skin vitality, Vitamin C is a clear frontrunner. For robust cellular protection and anti-ageing benefits, Vitamin E is a champion. For supporting thyroid function and boosting your body’s own antioxidant manufacturing systems, Selenium is absolutely essential.
The real victory comes from understanding that these nutrients work together in synergy. Rather than picking one and hoping for the best, the smartest strategy is to aim for a balanced intake of all three through a healthy, varied diet and, if needed, targeted supplementation.
Ready to boost your antioxidant defences? Explore our range of high-quality , including our popular , to find the right support for you.
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